[This may potentially become a series on common things that put me off evaluating software or even reading about it]
Please don't ever describe your software as "performant", it's a horrible term that essentially ascribes zero objective attributes to whatever you apply it. That aside, it seems to be used disproportionately by people who cannot otherwise fathom better descriptions of whatever they are attempting to pimp.
As such, I have become trained over the years to stop reading the moment I see it.
Nginx with uwsgi is the obvious choice for serving Python web applications, here I will describe my performant configuration that allows serving Hello, world 5 times a second with only 100ms latency. Therefore you should always use Nginx with uwsgi.
Nginx with uwsgi appears to offer the lowest latency variance for my application, which is designed to randomly fetch 12 byte strings over a transcontinental private circuit. Herein I describe my application's design and how you might learn from my choices.